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House Majority Leader Eric Cantor’s astonishing loss in his primary Tuesday to an obscure economics professor named Dave Brat sent shock waves through the House, the GOP and the Virginia political establishment.

Cantor’s defeat will trigger a major reassessment of what until now had been seen as a promising 2014 primary season for the Republican establishment.

Much will be written in the coming days on the reverberations, but here are five quick takeaways from Tuesday’s stunner in Virginia’s 7th congressional district:

Immigration reform is dead

Cantor was accused by tea party challenger Brat of supporting “amnesty,” though the congressman denied it.

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